Regeneration of transplanted islets

2010 Fiscal Year Final Research Report

• Project/Area Number: 21890293
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: General medical chemistry
• Research Institution: Fukuoka University
• Principal Investigator: KODAMA Shohta Fukuoka University, 医学部, 准教授 (90549338)
• Co-Investigator(Renkei-kenkyūsha): NISHINAKAMURA Hitomi 福岡大学, グローバルFUプログラム, 研究員 (90597692)
• Project Period (FY): 2009 – 2010
• Keywords: 再生 / 幹細胞 / 組織工学 / 膵島細胞 / 膵島移植

Research Abstract

Pancreatic stem cells were identified as the size restricted cells that were harbored in spleen. In addition, the size restricted small cells retained a homology between pancreas and spleen. Furthermore, the cells that were candidate for pancreatic stem cells were up-regulated the expression of critical genes, including Oct3/4, Sox2, c-Myc, Klf4 and Nanog, which were well-known genes as reprogramming for iPS cells.

Research Products

• [Journal Article] IKKβ Regulates Essential Functions of Vascular Endothelium Through Kinase-Dependent and -Independent Pathways. (2011)
  • Author(s): Ashida N., SenBanerjee S., Kodama S., Foo SY., Coggins M., Spencer J., Zamiri P., Shen D., Li L., Sciuto T., Dvorak A., Gerszten RE., Lin C., Karin M., Rosenzweig A.
  • Journal Title: Nat Commun 2 Pages: 318, DOI:10.1038,ncomms1317
  • Peer Reviewed
• [Journal Article] Proteomics Identifies Multipotency and Low Oncogenic Risk Stem Cells of the Spleen. (2010)
  • Author(s): Dieguez-Acuna F., Kodama S., Okubo Y., Paz AC., Gygi SP., Faustman DL.
  • Journal Title: Int J Biochem Cell Biol 42 Pages: 1651-60
  • Peer Reviewed
• [Presentation] A novel approach to prevent early loss of transplanted islets by targeting donor islets with a PPARγ agonist prior to transplantation. (2010)
  • Author(s): Mera T., Kojima D., Itoh T., Matsuoka N., Ono J., Kodama S., Yasunami Y.
  • Organizer: XXIII International Congress of the Transplantation Society
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 20100815-20100819
• [Presentation] Early loss of transplanted islets in the liver mice triggered by HMGB1 is prevented by antithrombin III. (2010)
  • Author(s): Kojima D., Mera T., Itoh T., Matsuoka N., Kodama S., Yasunami Y.
  • Organizer: XXIII International Congress of the Transplantation Society
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 20100815-20100819
• [Presentation] Islet Regeneration-Possible Inductions in Adult- (2010)
  • Author(s): Kodama S.
  • Organizer: The fourth international Conference on Cell Therapy
  • Place of Presentation: Seoul, South Korea
  • Year and Date: 2010-11-11
• [Remarks] ホームページ等
  • URL: http://resweb2.jhk.adm.fukuoka-u.ac.jp/FukuokaUnivHtml/info/5208/R107J.html