2010 Fiscal Year Final Research Report
Elucidation of membrane dynamics and molecular mechanism of bone resorption in osteoclast by using multi-photon microscopy
| Project/Area Number |
21890303
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Physical pharmacy
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
HIBI Terumasa Hokkaido University, 電子科学研究所, 助教 (50554292)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | 骨代謝 / 小胞輸送 / バイオイメージング / 多光子顕微鏡 / 蛍光蛋白質 |
|---|
| Research Abstract |
Bone is maintained by a balance between bone formation and resorption. The osteoclast is the cell that plays a major role in bone resorption in our body. In this study, to elucidate the molecular mechanism of bone resorption, vesicular trafficking in osteoclast was analyzed. By carrying out 4D-imaging, it becomes possible to analyze dynamics of acidic vesicles, probably involved in bone resorption, in living osteoclast not only horizontally but also vertically.
|
