2010 Fiscal Year Final Research Report
Development of PET imaging technique for cancer stem cell
| Project/Area Number |
21890308
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
NOZAKI Satoshi The Institute of Physical and Chemical Research, 分子プローブ動態応用研究チーム, 研究員 (10419707)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 癌幹細胞 / CD44 |
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| Research Abstract |
It is be clearly essential to kill the cancer stem cell for the radical cure of cancer.
Especially, It is important to develop the PET imaging technology for the cancer stem cell, and the specific cell death technology for cancer stem cell. Several researchers reported that CD44 molecules overexpressed with a variety of cancer stem cells. We tried the development of PET imaging technology and specific cell death technology for CD44 overexpressed-cancer stem cell. As a result, the CD44 molecules were not suitable for target molecules of PET imaging. Because, there were widely expressed the normal tissue. For the radical cure of cancer, it is required the more specific marker for cancer stem cell.
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