Searching endophenotype for schizophrenia focusing on schizotypal personality

2010 Fiscal Year Final Research Report

• Project/Area Number: 21890314
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: HORI Hiroaki 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第三部, 流動研究員 (10554397)
• Project Period (FY): 2009 – 2010
• Keywords: 統合失調症 / 遺伝子 / 神経科学 / 臨床

Research Abstract

We have investigated neurocognition, neuroendocrinological function and season of birth in relation to schizotypal personality and found qualitatively similar abnormalities and tendencies that are well established in schizophrenia, thereby providing evidence suggesting dimensionality between schizotypal personality and schizophrenia.

Research Products

• [Journal Article] Schizotypal personality in healthy adults is related to blunted cortisol responses to the combined dexamethasone/CRH test. (2011)
  • Author(s): Hori H, Teraishi T, Ozeki Y, et al(10名中1番目)
  • Journal Title: Neuropsychobiology 63(4) Pages: 232-241
  • Peer Reviewed
• [Journal Article] Attitudes toward schizophrenia in the general population, psychiatric staff, physicians, and psychiatrists : a web-based survey in Japan. (2011)
  • Author(s): Hori H, Richards M, Kawamoto Y, Kunugi H.
  • Journal Title: Psychiatry Res. 186(2-3) Pages: 183-189
  • Peer Reviewed
• [Journal Article] Possible association of the semaphorin 3D gene (SEMA3D) with schizophrenia. (2011)
  • Author(s): Fujii T, Uchiyama H, Yamamoto N, Hori H, Tatsumi M, Ishikawa M, Arima K, Higuchi T, Kunugi H.
  • Journal Title: J Psychiatr Res. 45(1) Pages: 47-53
  • Peer Reviewed
• [Journal Article] Relationships between psychological distress, coping styles, and HPA axis reactivity in healthy adults. (2010)
  • Author(s): Hori H, Ozeki Y, Teraishi T, et al(10名中1番目)
  • Journal Title: J Psychiatr Res. 44(14) Pages: 865-873
  • Peer Reviewed
• [Journal Article] Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder. (2010)
  • Author(s): Hashimoto R, Hashimoto H, Shintani N, Ohi K, Hori H, et al(14名中5番目)
  • Journal Title: Neurosci Lett. 468(3) Pages: 300-302
  • Peer Reviewed
• [Journal Article] A genetic variation in the dysbindin gene (DTNBP1) is associated with memory performance in healthy controls. (2010)
  • Author(s): Hashimoto R, Noguchi H, Hori H, et al(14名中3番目)
  • Journal Title: World J Biol Psychiatry 11(2 Pt 2) Pages: 431-438
  • Peer Reviewed
• [Journal Article] Interface between hypothalamic-pituitary-adrenal axis and brain-derived neurotrophic factor in depression. (2010)
  • Author(s): Kunugi H, Hori H, Adachi N, Numakawa T.
  • Journal Title: Psychiatry Clin Neurosci. 64(5) Pages: 447-459
• [Journal Article] Functional interactions between steroid hormones and neurotrophin BDNF. (2010)
  • Author(s): Numakawa T, Yokomaku D, Richards M, Hori H, Adachi N, Kunugi H.
  • Journal Title: World J Biol Chem. 1(5) Pages: 133-143
  • Peer Reviewed
• [Journal Article] ストレス反応・うつ病とニューロペプチド. (2010)
  • Author(s): 堀弘明、功刀浩
  • Journal Title: HORMONE FRONTIER 17 Pages: 31-37
• [Journal Article] Difference in Temperament and Character Inventory scores between depressed patients with bipolar II and unipolar major depressive disorders.
  • Author(s): Sasayama D, Hori H, Teraishi T, et al(15名中2番目)
  • Journal Title: J Affect Disord. in press
  • Peer Reviewed
• [Journal Article] Poor sleep is associated with exaggerated cortisol response to the combined dexamethasone/CRH test in a non-clinical population.
  • Author(s): Hori H, Teraishi T, Sasayama D, et al(10名中1番目)
  • Journal Title: J Psychiatr Res. in press
  • Peer Reviewed
• [Presentation] Schizotypal personality in healthy adults is related to blunted HPA axis reactivity. (2010)
  • Author(s): Hori H, Teraishi T, Ozeki Y, Matsuo J, Kawamoto Y, Kinoshita Y, Suto S, Higuchi T, Kunugi H.
  • Organizer: The 2nd Schizophrenia International Research Society Conference
  • Place of Presentation: Florence
  • Year and Date: 2010-12-04
• [Presentation] 統合失調症における視床下部-下垂体-副腎系機能:低用量デキサメタゾン抑制テストによる検討 (2010)
  • Author(s): 堀弘明、寺石俊也、篠山大明、石川正憲、功刀浩
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: 福岡県北九州市、リーガロイヤルホテル小倉
  • Year and Date: 2010-10-09
• [Presentation] Attitudes towards schizophrenia in the general population, psychiatric staff, physicians, and psychiatrists : A web-based survey in Japan. (2009)
  • Author(s): Hori H, Richards M, Kunugi H.
  • Organizer: The 15th Biennial Winter Workshop in Psychoses
  • Place of Presentation: Barcelona
  • Year and Date: 2009-11-17
• [Book] 統合失調症型パーソナリティと半球優位性(精神疾患とNIRS.)(編集:福田正人) (2009)
  • Author(s): 堀弘明、功刀浩
  • Total Pages: 202-211
  • Publisher: 中山書店
• [Remarks] 独立行政法人国立精神・神経医療研究センター神経研究所 疾病研究第三部 webページ
  • URL: http://www.ncnp.go.jp/nin/guide/r3/index.html