2022 Fiscal Year Annual Research Report
SCN2A自閉症に関する膜電位イメージングによる細胞体樹状突起シグナリングの解析
| Project/Area Number |
21F20712
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| Research Institution | Okinawa Institute of Science and Technology Graduate University |
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Principal Investigator |
Kuhn Bernd 沖縄科学技術大学院大学, 光学ニューロイメージングユニット, 教授 (90599557)
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| Co-Investigator(Kenkyū-buntansha) |
LI MELODY 沖縄科学技術大学院大学, 光学ニューロイメージングユニット, 外国人特別研究員
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| Project Period (FY) |
2021-09-28 – 2023-03-31
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| Keywords | Scn2a/Nav1.2 / neurological disorders / In vivo calcium imaging |
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| Outline of Annual Research Achievements |
Established a novel mouse model to study disease mechanisms underlying Scn2a neurodevelopmental disorders. For the first time, in vivo two-photo calcium imaging was performed in a Scn2a mouse model. We found that single neuron activities, as well as population co-activities were reduced in Scn2a insufficient mice during wakefulness. This may be one of the pathological mechanisms driving Scn2a neurodevelopmental disorders. Results was presented in the Japan neuroscience Society Annual Meeting and in the Okinawa Institute of Science and Technology (OIST) Internal Seminar.
A manuscript is in preparation and will be submitted to a peer reviewed journal.
Established collaboration opportunities between OIST and Florey Institute of Neuroscience and Mental Health, Australia.
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| Research Progress Status |
令和4年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
令和4年度が最終年度であるため、記入しない。
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