2022 Fiscal Year Annual Research Report
若年期の摂食制限の記憶がもつ成年期の摂食行動における役割
| Project/Area Number |
21F21082
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
McHugh Thomas 国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (50553731)
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| Co-Investigator(Kenkyū-buntansha) |
ZHOU YIJUN 国立研究開発法人理化学研究所, 脳神経科学研究センター, 外国人特別研究員
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| Project Period (FY) |
2021-04-28 – 2023-03-31
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| Keywords | hippocampus / hypothalmus / feeding / learning / context |
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| Outline of Annual Research Achievements |
Over the last fiscal year, we have made significant progress in our understanding of the neural circuit from subiculum in hippocampus to arcuate nucleus in hypothalamus. Using a virus combination of CRE recombinase and FLP recombinase, we observed the labelling cells in the subiculum. We have also employed viral-based manipulation methods to investigate the role of this circuit in both feeding and learning components. Meanwhile, the behavior paradigm also confirmed that the internal state of animals (hunger or satiety) could be a context for adaptive behaviors. These findings have important implications for our understanding of neural circuits involved in feeding and learning and may pave the way for targeted therapies for related disorders.
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| Research Progress Status |
令和4年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
令和4年度が最終年度であるため、記入しない。
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