Preparation of sol-gel bioactive glass fibres with graded structure and evaluation of their cell compatibility

2023 Fiscal Year Final Research Report

• Project/Area Number: 21H01621
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 26020:Inorganic materials and properties-related
• Research Institution: Nagoya Institute of Technology
• Principal Investigator: obata akiko 名古屋工業大学, 工学(系)研究科(研究院), 准教授 (40402656)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 生体材料 / ガラス / 細胞 / 繊維

Outline of Final Research Achievements

In this study, we attempted to develop bioactive glass fibers that have the function of promoting the regeneration of biological tissue. The glass was synthesized using the sol-gel method, which is a liquid phase method, and the electrospinning method was used to fabricate the fibers. We tried to create fibers with a core-shell structure, aiming to elute any inorganic ion from the glass fibers, thereby activating cells and promoting tissue regeneration. We also designed the composition of the glass to achieve ideal ion supply behavior. Furthermore, cell culture tests revealed that certain ions exhibit a promoting effect in the tissue regeneration process mediated by immune system cells.

Free Research Field

生体材料

Academic Significance and Societal Importance of the Research Achievements

超高齢社会に突入している日本において、健康寿命を延ばすための高機能な生体材料が求められている。特に骨疾患治療用の材料は需要が高いと見込まれる。従来の材料は硬く脆いものが多かったが、本研究では綿の様な柔軟性のある繊維をガラス単体で作製することに成功した。また、細胞を活性化させる機能を有するため、骨などの組織の再生を促進することが期待される。将来的には、綿状ガラスという新しい生体材料を提供するだけでなく、生体以外の分野へも展開できると考える。