2023 Fiscal Year Final Research Report
Magnetic biosensing based on modulation of magnetic relaxation induced by interaction between magnetic naoparticles and biomelecules
| Project/Area Number |
21H01760
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 28030:Nanomaterials-related
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 磁気バイオセンシング / 磁性ナノ粒子 / 磁気緩和 / 分子間相互作用 / 緩和時間分布解析 |
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| Outline of Final Research Achievements |
This study has been conducted to clarify the effect of the interaction between magnetic nanoparticle and biomolecules in fluid environments such as body fluids and biological tissues on the magnetic relaxation of nanoparticles, and to establish the principle of liquid biosensing based on a method to magnetically detect the modulation of the relaxation. The results suggested that adjusting the solution environment, such as salt concentration, is important for efficient and specific detection of the interaction between magnetic nanoparticle labels and target biomolecules. In addition, even if the interaction between the labels and biomolecules is nonuniform and the modulation of the frequency spectrum is small, the concentration of a biomolecule can be estimated with higher accuracy by introducing machine learning into magnetic nanoparticle-biomolecule cluster distribution analysis, leading to the capability of highly sensitive detection.
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| Free Research Field |
磁気工学
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| Academic Significance and Societal Importance of the Research Achievements |
リキッドバイオプシーなど生体にかかわる診断のためのセンシング技術として、磁性ナノ粒子をラベルとする磁気センシング技術に寄与する研究である。学術的には生体環境に近い溶液中で、生体分子とラベルとなる磁性ナノ粒子の相互作用、特に磁気緩和現象がどのように変調されるかを明らかにすることに意義があり、実用的な観点からは高感度なバイオセンシングに供するために、磁性ナノ粒子ラベルをどのように設計するかだけでなく、それらが相互作用した結果を適切な診断に供するのに必要な溶液環境をも明らかにするという意義を有している。より高感度なセンシング技術に開拓により、高度な診断技術につながると期待できる。
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