Can the improvement of intestinal abnormalities in lipid metabolism cause the improvement of fatty liver and obesity?

2023 Fiscal Year Final Research Report

• Project/Area Number: 21H02146
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 38050:Food sciences-related
• Research Institution: Tokyo University of Agriculture
• Principal Investigator: Takahashi Nobuyuki 東京農業大学, 応用生物科学部, 教授 (50370135)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 食後高脂血症 / 肥満 / 脂質代謝 / 高脂肪食 / 消化管 / 炎症

Outline of Final Research Achievements

Fatty liver and obesity are important risk factors for the development of arteriosclerotic diseases. At the same time, postprandial hyperlipidemia, a postprandial increase in blood triglyceride concentration, is also attracting attention as a risk factor for the development of atherosclerotic disease with a higher correlation than that of fasting blood triglyceride concentration. However, it is not clear how the improvement of postprandial hyperlipidemia affects other risk factors such as fatty liver and obesity. In this study, we will examine the mechanism of postprandial hyperlipidemia exacerbation in more detail and examine how fatty liver and obesity are affected by long-term favorable postprandial hyperlipidemia using genetically modified mice.

Free Research Field

分子代謝生理学

Academic Significance and Societal Importance of the Research Achievements

これまで動脈硬化性疾患の発症リスクとしての食後高脂血症は、消化器内科の分野では早くから注目されている。しかし詳細な作用メカニズムはもちろん食後高脂血症の悪化メカニズムの検討は行われていない。したがって本研究での成果は、食後高脂血症への注目を高めることに加え、脂肪肝や肥満の予防・改善を目的に食後高脂血症の悪化改善をターゲットとした薬剤・機能性食品成分の開発への動機付けを強めることが期待される。また食後高脂血症悪化を改善する新規食品成分の同定により、新たな機能性食品の開発や創薬シーズのスクリーニングにも寄与しうるため、創造性も高いと考えている。