2023 Fiscal Year Final Research Report
Functional regulation of immune cells in the metabolic disease prevention mechanism by brown seaweed fucoxanthin
| Project/Area Number |
21H02276
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 40040:Aquatic life science-related
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
岡松 優子 北海道大学, 獣医学研究院, 教授 (90527178)
高谷 直己 北海道大学, 水産科学研究院, 助教 (40801501)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | フコキサンチン / イムノカロテノイド / マクロファージ / T細胞 / 加齢肥満予防 / 抗炎症作用 / 褐藻 |
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| Outline of Final Research Achievements |
Fucoxanthin contained in brown seaweeds was shown to affect macrophages and T cell subsets in white adipose tissue (WAT) of obese mice and liver of non-alcoholic steatohepatitis-induced mice. It was also confirmed that fucoxanthinol, an in vivo metabolite of fucoxanthin, accumulated in the mitochondria of the liver, suggesting that it regulates organelle function. Furthermore, fucoxanthin suppressed weight gain and WAT increase in aging mice fed high-fat diet, decreased mRNA expression of F4/80 macrophage marker in WAT and liver, and changed the number of CD4+ helper T cells and CD8+ killer T cells. These results suggest that fucoxanthin has a regulatory function on immune cell groups, and there is interest in its relationship with the mechanism of preventing aged-related metabolic diseases.
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| Free Research Field |
水産食品化学、分子栄養学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究で見いだされたフコキサンチンの免疫細胞調節は、海洋性カロテノイドによる自然および獲得免疫に対する機能調節を期待させるものであり、健康機能を有する「イムノカロテノイド」創出への期待が持たれる。特に、超高齢化の時代を迎え加齢性疾患の予防が大きな課題となっている今日において、フコキサンチンが高脂肪食投与の高齢マウスに対して体重増加およびWATの増大抑制効果を示すとともに、マクロファージやT細胞サブセットに対する調節機能を示唆した成果は、新たな機能性食品の開発につながる意義深い成果である。
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