2023 Fiscal Year Final Research Report
Regulation of hemangioblst development by partial Epithelial Mesenchymal Transition
| Project/Area Number |
21H02490
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 44020:Developmental biology-related
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| Research Institution | Kumamoto University |
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Principal Investigator |
Sheng Guojun 熊本大学, 国際先端医学研究機構, 特別招聘教授 (20399439)
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| Co-Investigator(Kenkyū-buntansha) |
永井 宏樹 熊本大学, 国際先端医学研究機構, リサーチ・スペシャリスト (80772508)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | chicken / hemagioblast / hematopoiesis / vasculogenesis / ETV2 / NPAS4L |
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| Outline of Final Research Achievements |
We show that ancestral amniotes contain both ETV2 and NPAS4L genes and that ETV2, although absent in avian genomes, is able to initiate endothelial differentiation program, but not hematopoietic differentiation program.
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| Free Research Field |
Developmental morphogenesis
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| Academic Significance and Societal Importance of the Research Achievements |
We offer an evo-devo example of how critical master regulators of blood and
vessel development can still change and evolve. Socially, our work
highlighted the importance of domestic and international collaborations.
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