2023 Fiscal Year Final Research Report
Dissection of iron deficiency response involving novel short peptide FEP1.
| Project/Area Number |
21H02509
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 44030:Plant molecular biology and physiology-related
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
馬 建鋒 岡山大学, 資源植物科学研究所, 教授 (80260389)
横正 健剛 岡山大学, 資源植物科学研究所, 准教授 (50790622)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 鉄欠乏応答 / 短鎖ペプチド / シロイヌナズナ / 網羅的遺伝子発現解析 / シダ植物 |
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| Outline of Final Research Achievements |
Plants efficiently absorb essential iron from the soil, a critical resource on which many organisms, including humans, depend for survival. While significant progress has been made in understanding plant iron homeostasis, identifying iron transporters and transcription factors regulating their gene expression, there remain many unknowns regarding inter-tissue iron transport and communication. This research project aims to elucidate the function of a novel short peptide, FEP1, in iron deficiency response. Through the analysis of FEP1 loss-of-function mutants, ectopic expression transformants, and the study of FEP1-like genes in ferns, the ancestors of vascular plants, we have demonstrated that FEP1 plays an important role in vascular tissues and may function by moving between cells.
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| Free Research Field |
植物分子遺伝学
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| Academic Significance and Societal Importance of the Research Achievements |
FEP/IMAペプチドの鉄欠乏応答制御における分子機構の理解は進んだが、組織間鉄輸送における生理機能、さらにその機能における短鎖ペプチドの必然性については、不明な点が多い。本課題研究では、fep1変異の詳細な解析からFEP1が細胞・組織間鉄輸送において重要な役割を持つことを明示した。この知見は、鉄応答機構の理解を推進し、また農作物の鉄吸収の制御を可能にする技術の開発などの応用展開も期待される。また、ミトコンドリアmRNAのpolyA付加制御に関わる因子の変異ags2を同定した。AGS2の研究によりミトコンドリア機能制御に関する多くの知見の獲得が期待される、
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