2023 Fiscal Year Final Research Report
Regulation of sensory modalities by microglia and their contribution to psychiatric diseases
| Project/Area Number |
21H02662
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 48020:Physiology-related
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| Research Institution | National Institute for Physiological Sciences (2023)
Nagoya University (2021-2022) |
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Principal Investigator |
WAKE Hiroaki 生理学研究所, 基盤神経科学研究領域, 教授 (90455220)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | ミクログリア / 異種感覚の優位性 |
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| Outline of Final Research Achievements |
We have identified the contribution of microglia to heterogeneous sensory plasticity and examined their involvement in psychiatric disease pathology.First, we showed that there is a projection from each primary sensory cortex to V2L, a higher visual cortex, and examined the functional response of neurons in V2L. We found that the response of V2L is normally suppressed by mustache stimulation, but its activity frequency is enhanced by visual deprivation. Detailed examination revealed that microglia contribute to the acquisition of excitability of excitatory neurons by contacting the peri-excitatory neurons and stripping inhibitory synapses upon visual deprivation. We also found that this acquired excitability contributes to sensory discrimination of whiskers.
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| Free Research Field |
神経科学
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| Academic Significance and Societal Importance of the Research Achievements |
多種な感覚がどのように統合されているのかを理解するために高次感覚野での感覚の優位性を理解し、それによる統合のメカニズムを探ることで、感覚統合に異常を有する精神疾患などへの病態を明らかにすることができる。これによって精神疾患に対する新規治療法の開発を目指すことが可能となる
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