2023 Fiscal Year Final Research Report
The PI4-Kinase Complex and Its Role in Plasma Membrane Lipid Homeostasis
| Project/Area Number |
21H02694
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 49010:Pathological biochemistry-related
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | plasma membrane / PI4P |
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| Outline of Final Research Achievements |
The lipids that form the plasma membrane fulfill many vital functions, including barrier functions and the regulation of signal transduction. Nonetheless, the details regarding their homeostasis regulation are not well understood. In this study, we aim to clarify these mechanisms, particularly from the standpoint of lipid transport control and signal transduction regulation. By identifying novel lipid transport proteins and developing new probes and biosensors for cell membrane lipids, we have shed light on part of the dynamic regulation mechanism of cell membrane lipids.
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| Free Research Field |
細胞生物学
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| Academic Significance and Societal Importance of the Research Achievements |
細胞膜は、バリア機能や細胞内外のシグナル受容・伝達など、細胞の生命活動に必須な様々な役割を担う。その主要構成分子である脂質はそれら生理機能の制御の中心的役割を担っており、その制御破綻が種々の疾患に関与することからもその生理的重要性は明らかである。本研究により明らかになった知見は、細胞膜が担う様々な現象のさらなる理解や疾患機序解明、さらには新たな治療薬開発などに結びつく可能性が期待される。
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