Analysis of bacterial strategies that counteract host defense cross-talk

2023 Fiscal Year Final Research Report

• Project/Area Number: 21H02728
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 49050:Bacteriology-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Ashida Hiroshi 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (10535115)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 腸管病原菌 / エフェクター / 細胞死 / 炎症

Outline of Final Research Achievements

In this study, we have identified bacterial strategy that counteracts host defense crosstalk. EPEC delivers effector to prevent necroptosis, while it becomes a cue to trigger pyroptosis. To counteract this, EPEC delivers another effector F and prevents pyroptosis. In addition, Shigella effector O downregulates host inflammatory responses, while induces apoptosis. To counteract effector O-triggered apoptosis, Shigella delivers OspC1 effector and prevents apoptosis. In conclusion, we found that enteric bacterial pathogens prevent host defense crosstalk through spatiotemporal regulation by effectors.

Free Research Field

細菌学

Academic Significance and Societal Importance of the Research Achievements

本研究では、腸管病原菌感染における生体防御クロストーク発動機構とそれに対する腸管病原菌の感染戦略を解明した。本研究により得られた知見は未だ未解明な点が多い腸管病原菌の感染機構解明に寄与した。また、腸管病原菌による新たな感染戦略を標的とする創薬・ワクチン開発へとつながることが期待される。