2023 Fiscal Year Final Research Report
In vivo analysis of gut microbiota which prevents the intestinal botulism
| Project/Area Number |
21H02729
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 49050:Bacteriology-related
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松村 拓大 金沢大学, 医学系, 准教授 (00456930)
小林 伸英 金沢大学, 医学系, 助教 (30712799)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | ボツリヌス菌 / Clostridium botulinum / 腸内細菌 / ボツリヌス症 |
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| Outline of Final Research Achievements |
Colonization of the host intestines by Clostridium botulinum causes infant botulism with severe paralysis. Healthy adults are resistant to C. botulinum infection, whereas infants are susceptible. Past studies revealed that adult intestinal microbiota is crucial for protection against C. botulinum infection. However, specific bacterial species and the detailed mechanism of colonization resistance currently remain unknown. In this study, we found Clostridia is responsible for colonization resistance against C. botulinum. Furthermore, we identified single Clostridia strain enough to protect against C. botulinum infection. The results of this study expand our understanding of the pathogenesis of infant botulism.
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| Free Research Field |
細菌学
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| Academic Significance and Societal Importance of the Research Achievements |
乳児ボツリヌス症は、日本においては年間数例と比較的稀な疾患ではあるが、罹患した場合は、治療法が存在しない。本疾患の罹患リスクを下げるために、一歳未満の乳児には、ボツリヌス菌芽胞を含んでいる可能性が高いことで知られている蜂蜜の摂取を控えるといった予防法が採られているのみである。本感染症を抑制する腸内細菌が同定できれば、これまでに実現できなかった本疾患の根本的な予防法や治療法を確立するための鍵となる基礎的知見が得られる。
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