2023 Fiscal Year Final Research Report
Analysis of a multifunctional Wnt/c-Myc target lncRNA in tumorigenesis
| Project/Area Number |
21H02771
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 50010:Tumor biology-related
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| Research Institution | Kansai Medical University (2023)
Institute of Physical and Chemical Research (2021-2022) |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | Wnt / c-Myc / LncRNA |
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| Outline of Final Research Achievements |
Aberrant activation of Wnt/b-catenin signaling is a major driving force in colon cancer. Wnt/b-catenin signaling induces the expression of the transcription factor c-Myc, leading to cell proliferation and tumorigenesis. We showed that MYU, a direct target lncRNA of Wnt/c-Myc, generated small functional peptide by molecular and biochemical analyses. We also found candidate proteins associated with MYU-derived peptide and they would provide clues to investigate the mechanism behind Wnt/c-Myc/MYU-mediated tumor growth.
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| Free Research Field |
分子生物学
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| Academic Significance and Societal Importance of the Research Achievements |
高等生物には膨大な数のlncRNAが存在しているが、ほとんどのlncRNAについては生理機能が未だに不明のままである。さらに、lncRNAが疾患発症に及ぼす影響とその作用機序の解明にも充分に迫ることが出来ていない。本研究では、non-coding RNAとして分類されてきたlnRNA MYUが機能を有したペプチドを産み出しているという新たな一面を見出した。本研究で得られた成果は、lncRNAが関わる細胞増殖制御機構を明らかにするための重要な知見となり得ると考えられた。
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