Fundamental research for elucidation of the molecular structure mechanism of oxidative phosphorylation enzymes and development of drug discovery

2023 Fiscal Year Final Research Report

• Project/Area Number: 21H02914
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Osaka University
• Principal Investigator: Takashima Seiji 大阪大学, 大学院生命機能研究科, 教授 (90379272)
• Co-Investigator(Kenkyū-buntansha): 加藤 久和 大阪大学, 大学院医学系研究科, 助教 (30589312) ; 松岡 研 大阪大学, 大学院医学系研究科, 助教 (90826190)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 心不全 / エネルギー需給バランス / ミトコンドリア / 微小循環障害 / ATP合成酵素

Outline of Final Research Achievements

In Japan, the number of patients with heart failure is rapidly increasing as the population ages, and this has become an important public health issue. On the other hand, effective treatment methods for heart failure are limited, and the development of therapeutic drugs has not progressed. This study focused on specific factors related to the onset and exacerbation of heart failure, and clarified the role of these factors in the pathology of heart failure. Furthermore, we proceeded with the development of a completely new heart failure treatment targeting this factor, and achieved conceptual verification of its efficacy in vivo.

Free Research Field

循環器内科

Academic Significance and Societal Importance of the Research Achievements

本事業においては、酸化的リン酸化酵素群の活性化機構を解明すると同時にタンパク質分解抑制化合物スクリーニング系の確立およびこの系を利用したFirst in Classの心不全治療薬の開発を物質特許出願まで行った。分子機構の解明は今後の生体内エネルギー代謝を考える上で学術的に重要な意義をもち、また新規で汎用性の高い薬剤アッセイ系の構築と実用実践は、我が国の新薬創生促進につながると期待される。