2023 Fiscal Year Final Research Report
Dynamism of spaciotemporal trafficking of hematopoietic stem/progenitor cells
| Project/Area Number |
21H02947
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 54010:Hematology and medical oncology-related
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 移動 / 造血幹細胞 |
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| Outline of Final Research Achievements |
One of the features of hematopoietic stem cells (HSCs) is “mobility”. In MDS/MPN, normal HSCs are gradually replaced with abnormal ones in the bone marrow. This phenomenon has never been analyzed in the aspect of HSC mobility. The aim of this research is to elucidate signaling relays that govern the HSC mobility in normal and diseased hematopoietic tissues.
In the study of murine model of G-CSF-induced HSC mobilization from bone marrow to circulation, we found that FGF23 from erythroblasts and PPARδ in neutrophils strikingly regulate HSC mobility. Currently, the exact roles of these pathways in the maintenance/replacement of HSCs in MDS/MPN are under investigation by generating cell specific conditional knockout mice.
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| Free Research Field |
造血環境
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| Academic Significance and Societal Importance of the Research Achievements |
造血幹細胞の機能の中で解析が遅れていた移動能についての理解の前進があり、実臨床での患者やドナーの体内で引き起こされる反応と臨床的に問題になる副反応や動員効率のばらつきなどについて一定の科学的説明ができるようになってきたことは意義が高い。特に、同じ交感神経系からの刺激で動員促進と動員抑制の相反する効果が同時に発動されることは興味深い。造血器疾患にこの理論を応用するには、更に継続した研究が必要である。
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