2023 Fiscal Year Final Research Report
Analysis of the pathogenesis of tacrolimus nephropathy by integrating drug distribution kinetics in renal tissue and metabolomic analysis
| Project/Area Number |
21H03069
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 56030:Urology-related
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| Research Institution | Jichi Medical University |
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Principal Investigator |
Iwami Daiki 自治医科大学, 医学部, 教授 (80581115)
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| Co-Investigator(Kenkyū-buntansha) |
西田 翔 自治医科大学, 医学部, 助教 (00909799)
佐久間 康成 自治医科大学, 医学部, 教授 (10296105)
上田 祐司 獨協医科大学, 医学部, 准教授 (10364556)
南園 京子 自治医科大学, 医学部, 助教 (10885586)
相澤 健一 自治医科大学, 医学部, 准教授 (70436484)
木下 善隆 自治医科大学, 医学部, 助教 (30856282)
清水 俊洋 自治医科大学, 医学部, 講師 (40746575)
片野 咲 自治医科大学, 医学部, 臨床助教 (20804933)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | タクロリムス / 腎症 / 腎移植 / 臓器移植 |
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| Outline of Final Research Achievements |
TAC neppropathy was associated with duration of TAC administration but not blood or intrarenal TAC concentration in the clinical biopsy samples.
In the mouse TAC nephropathy model, metabolome analysis revealed that significant reduction of carnithine, which is associated with maintenance of mitochondria function in the kidney. These results suggested that TAC nephropathy was induced by the dysfunction of mitochondria through reduction of carnithine and its metabolite associated with chronic TAC administration.
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| Free Research Field |
腎移植
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の成果により臓器移植後の予後に影響を及ぼしていたTAC腎症発症機序の一部が解明された。本研究の成果を通じて、今まで治療法の存在しなかった臓器移植後のTAC腎症の治療及び予防法の開発につながる可能性がある。
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