2023 Fiscal Year Final Research Report
Development of fertilization therapy for stem cell-depleted diseases
| Project/Area Number |
21H03101
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 56070:Plastic and reconstructive surgery-related
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 幹細胞 / 放射線治療 / 放射線障害 |
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| Outline of Final Research Achievements |
In this study, we prepared an animal model for stem cell-depleted conditions,which is irradiation chronic damage established at 6 months after multiple doses of a radiotherapy.We treated the chronic damage using adipose-derived stem cells or related products and got positive results. Furthermore, we tested a prophylactic treatment using the same products perfromed immediately after radiotherapy. We found the chronic damage can be well prevented by the prophilactic treatment, indicating a stem cell theprapy comibining with any types of radiotheprapies in the future.
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| Free Research Field |
形成外科
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| Academic Significance and Societal Importance of the Research Achievements |
本成果は、放射線治療に伴う弊害、とくに晩期障害によるQOLの低下を克服するために、予防的な再生医療の可能性を示している。すなわち、あらゆる放射線治療は、幹細胞投与と併用することにより、その負の側面をなくすことができるため、放射線治療に対して非常に大きなインパクトを与える成果である。今後は、すべての放射線治療に幹細胞を用いた再生医療が併用されるようになることが示唆された。
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