A novel therapeutics for keloids associated with mechanotransduction.

2023 Fiscal Year Final Research Report

• Project/Area Number: 21H03102
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 56070:Plastic and reconstructive surgery-related
• Research Institution: Keio University
• Principal Investigator: OKABE Keisuke 慶應義塾大学, 医学部(信濃町), 講師 (50445350)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: ケロイド / メカニカルストレス

Outline of Final Research Achievements

Keloids are fibroproliferative diseases of the skin, and mechanical stress is known to be involved in their development and exacerbation, but the specific genes and molecules involved are unknown. Another barrier to elucidating the pathogenesis of keloids is the lack of appropriate animal models. In this study, we developed culture and animal models subjected to mechanical stress and compared them with actual tissues of keloid patients to search for factors of mechanical stress associated with the pathogenesis of keloids. Comprehensive gene expression analysis using microarrays was performed on both the culture and animal models, and a group of genes that were altered were extracted. We will continue experiments to validate the individual factors.

Free Research Field

形成外科学

Academic Significance and Societal Importance of the Research Achievements

ケロイドや肥厚性瘢痕に苦しむ患者は膨大な数に及ぶが、それらに対する有効な治療手段は限定的であり、新規治療方法の開発が社会的に求められている。今回、ケロイドの発生と増悪にメカニカルストレスが関与することに着目し、モデルを確立して病態に関与する可能性のある遺伝子を抽出することに成功した。これらの成果を基盤として今後の研究を行うことにより新規治療の開発が可能なると思われる。