Developing innovative sepsis treatments inspired by pain

2023 Fiscal Year Final Research Report

• Project/Area Number: 21H03114
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 57020:Oral pathobiological science-related
• Research Institution: Aichi Medical University (2023); National Institute for Physiological Sciences (2021-2022)
• Principal Investigator: Maruyama Kenta 愛知医科大学, 医学部, 教授 (60724119)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 痛覚 / 免疫 / 脳

Outline of Final Research Achievements

This study raises the possibility that overproduction of QUIN, accompanied by increased expression of IDO1 in brain microglia, is the bona-fide cause of death in sepsis. Future research on sepsis from the viewpoint of senso-immunology, redefining sepsis as a "metabolic disorder of the brain",may lead to the development of innovative and life-saving methods for sepsis.

Free Research Field

感覚免疫学

Academic Significance and Societal Importance of the Research Achievements

LPS を投与されたマウスの痛覚神経は脳に浸潤する性質をもつReg3gを産生し、Reg3gはミクログリアのIDO1の発現を抑制することで脳を保護していることが明らかとなった。痛覚神経による脳を標的とするこれまで全く知られていない新しい免疫寛容機構の一端が解明されたものと考えている。