• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2022 Fiscal Year Annual Research Report

潜在的な薬剤性有害事象を自動的に検出する汎用性の高いアルゴリズムに関する研究

Research Project

Project/Area Number 21H03176
Research InstitutionHyogo Medical University

Principal Investigator

森本 剛  兵庫医科大学, 医学部, 教授 (30378640)

Co-Investigator(Kenkyū-buntansha) 太田 好紀  兵庫医科大学, 医学部, 特任准教授 (10516404)
作間 未織  兵庫医科大学, 医学部, 准教授 (60349587)
武内 治郎  兵庫医科大学, 医学部, 助教 (60791324)
Project Period (FY) 2021-04-01 – 2024-03-31
Keywords医原性有害事象 / 医療安全 / 臨床疫学 / 機械学習
Outline of Annual Research Achievements

本研究は、入院患者や外来患者において、日常的に発生していることが分かりつつある薬剤性有害事象について、診療中には薬剤性とは認識されず見逃されている、潜在的な薬剤性有害事象を電子カルテシステム上で自動的に予測し、検出するアルゴリズムを開発することを目的としている。
2022年度は、急性期病棟入院患者における潜在的な薬剤性有害事象に関する前向きコホート研究を行い、対象施設の全診療科に入院した全患者を対象に、電子カルテシステムから経時的に患者背景(潜在的薬剤性有害事象リスク因子)を収集する予定であったが、新型コロナウイルス感染拡大のため、研究者が病院に訪問することが出来ず、データ収集を2023年度にかけて実施した。病院に訪問することが出来るようになった後、カルテ上の診療記録や看護記録、検査記録、画像診断情報などを基に、薬剤性有害事象の可能性がある診療イベントの抽出を行った。データ収集後に、研究者によるケースレビューを行い、客観的評価基準に従って薬剤性有害事象やエラーを分析した。
薬剤性有害事象について、薬剤の種類、症状の内容、重症度、予後などの詳細について分類し、発生前後の診療経過や情報源、患者の健康被害に対する医療従事者の対応の有無や内容によって、診療中に医療従事者に薬剤性有害事象とは認識されなかった潜在的な薬剤性有害事象の同定を行った。
これらの解析を通じて、潜在的な薬剤性有害事象を自動的に検出する汎用性の高いアルゴリズムを作成することができれば、日常診療において安全な薬物治療に繋がることが期待される。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

新型コロナウイルス感染の収束を受けて、研究補助員の雇用も行い、当初予定の研究データの収集は実施できた。データ処理を行った上で論文化の予定であり、概ね予定通り進んでいる。

Strategy for Future Research Activity

本研究の収集データを機械学習に導入するためには、堅牢な薬剤有害事象の分類が必要である。そのため、薬剤性有害事象の可能性がある診療イベントのケースレビューには、十分な時間をかけて、客観的評価基準に従って薬剤性有害事象やエラーを分類し、アルゴリズムの作成に進める予定である。
本研究で得られたアルゴリズムに関与する要因を分析することで、薬剤性有害事象のリスクが高い診療環境や医療行為の特性を明らかにすることができる。薬剤性有害事象のリスクが高い診療環境や医療行為、診療科などの特性を詳細に分析することで、薬剤自体の薬効や特性に加えて、複合的な要因やプロセスを解明することが出来れば、より安全な薬物治療の提供に繋げることが出来る。

  • Research Products

    (24 results)

All 2024 2023 2022

All Journal Article (17 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 17 results,  Open Access: 17 results) Presentation (7 results) (of which Int'l Joint Research: 7 results)

  • [Journal Article] Adverse Events in Pediatric Inpatients: The Japan Adverse Event Study2024

    • Author(s)
      Sakuma M, Ohta Y, Takeuchi J, Yuza Y, Ida H, Bates DW, Morimoto T
    • Journal Title

      Journal of Patient Safety

      Volume: 20 Pages: 38~44

    • DOI

      10.1097/PTS.0000000000001180

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Incidence of and factors associated with emergency caesarean section in pregnant women with gestational diabetes mellitus: A retrospective cohort study2024

    • Author(s)
      Nabika S, Nakamura T, Ito Y, Nagasawa A, Morimoto T
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 50 Pages: 849~855

    • DOI

      10.1111/jog.15921

    • Peer Reviewed / Open Access
  • [Journal Article] Anemia and Rehabilitation Outcomes in Patients Undergoing Convalescent Rehabilitation2024

    • Author(s)
      Arai H, Nozoe M, Kamiya K, Matsumoto S, Morimoto T
    • Journal Title

      Archives of Physical Medicine and Rehabilitation

      Volume: 105 Pages: 539~545

    • DOI

      10.1016/j.apmr.2023.10.017

    • Peer Reviewed / Open Access
  • [Journal Article] Safety and Effectiveness of Apixaban Versus Warfarin in Japanese Patients with Nonvalvular Atrial Fibrillation Stratified by Renal Function: A Retrospective Cohort Study2023

    • Author(s)
      Morimoto T, Hoshino H, Matsuo Y, Ibuki T, Miyata K, Koretsune Y
    • Journal Title

      American Journal of Cardiovascular Drugs

      Volume: 23 Pages: 721~733

    • DOI

      10.1007/s40256-023-00611-7

    • Peer Reviewed / Open Access
  • [Journal Article] Monitoring for adverse drug events of high-risk medications with a computerized clinical decision support system: a prospective cohort study2023

    • Author(s)
      Nezu M, Sakuma M, Nakamura T, Sonoyama T, Matsumoto C, Takeuchi J, Ohta Y, Kosaka S, Morimoto T
    • Journal Title

      International Journal for Quality in Health Care

      Volume: 35 Pages: mzad095

    • DOI

      10.1093/intqhc/mzad095

    • Peer Reviewed / Open Access
  • [Journal Article] Patient-reported outcomes for quality of care among pediatric patients2023

    • Author(s)
      Sakuma M, Morimoto T
    • Journal Title

      International Journal for Quality in Health Care

      Volume: 35 Pages: mzad020

    • DOI

      10.1093/intqhc/mzad020

    • Peer Reviewed / Open Access
  • [Journal Article] Impact of anemia on major bleeding in patients taking oral anticoagulants for nonvalvular atrial fibrillation2023

    • Author(s)
      Kinjo N, Ueda S, Uchida K, Sakakibara F, Nezu M, Arai H, Morimoto T
    • Journal Title

      Journal of Arrhythmia

      Volume: 39 Pages: 556~565

    • DOI

      10.1002/joa3.12885

    • Peer Reviewed / Open Access
  • [Journal Article] Prediction of ESBL-producing E coli for suspected urinary tract infection2023

    • Author(s)
      Higuchi H, Nakamura T, Mashino J, Imada T, Morimoto T
    • Journal Title

      Urologia Journal

      Volume: 90 Pages: 151~156

    • DOI

      10.1177/03915603221103438

    • Peer Reviewed / Open Access
  • [Journal Article] Effectiveness of a computerized clinical decision support system for prevention of glucocorticoid-induced osteoporosis2022

    • Author(s)
      Morikawa T, Sakuma M, Nakamura T, Sonoyama T, Matsumoto C, Takeuchi J, Ohta Y, Kosaka S, Morimoto T
    • Journal Title

      Scientific Reports

      Volume: 12 Pages: 14967

    • DOI

      10.1038/s41598-022-19079-7

    • Peer Reviewed / Open Access
  • [Journal Article] Association between anemic status on admission and clinical outcomes of acute large vessel occlusion2022

    • Author(s)
      Fujiwara S, Sakai N, Imamura H, Ohara N, Tanaka K, Yamagami H, Matsumoto Y, Takeuchi M, Uchida K, Yoshimura S, Morimoto T
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 440 Pages: 120343~120343

    • DOI

      10.1016/j.jns.2022.120343

    • Peer Reviewed / Open Access
  • [Journal Article] Association between Acid-Suppressive Drugs and Clinical Outcomes in Patients with Nonvalvular Atrial Fibrillation2022

    • Author(s)
      Arai H, Ueda S, Uchida K, Sakakibara F, Kinjo N, Nezu M, Morimoto T
    • Journal Title

      Drugs in R D

      Volume: 22 Pages: 213~222

    • DOI

      10.1007/s40268-022-00392-5

    • Peer Reviewed / Open Access
  • [Journal Article] Association between dihydropyridine calcium channel blockers and ischemic strokes in patients with nonvalvular atrial fibrillation2022

    • Author(s)
      Sakakibara F, Ueda S, Uchida K, Kinjo N, Arai H, Nezu M, Morimoto T
    • Journal Title

      Hypertension Research

      Volume: 45 Pages: 1028~1036

    • DOI

      10.1038/s41440-022-00855-x

    • Peer Reviewed / Open Access
  • [Journal Article] Impact of prior antiplatelet therapy on outcomes of endovascular therapy for acute ischemic stroke with large vessel occlusion: Sub-analysis of the RESCUE-Japan Registry 22022

    • Author(s)
      Fujiwara S, Sakai N, Imamura H, Ohara N, Tanaka K, Yamagami H, Matsumoto Y, Takeuchi M, Uchida K, Yoshimura S, Morimoto T
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 438 Pages: 120278~120278

    • DOI

      10.1016/j.jns.2022.120278

    • Peer Reviewed / Open Access
  • [Journal Article] Low Serum Total Protein at Admission Predicts in-Hospital Mortality Among General Inpatients: Historical Cohort Study2022

    • Author(s)
      Inoue M, Takeuchi J, Sakuma M, Nakamura T, Morimoto T
    • Journal Title

      International Journal of General Medicine

      Volume: Volume 15 Pages: 7941~7949

    • DOI

      10.2147/IJGM.S385798

    • Peer Reviewed / Open Access
  • [Journal Article] Drug-Related Pneumonitis Induced by Osimertinib as First-Line Treatment for Epidermal Growth Factor Receptor Mutation-Positive Non-Small Cell Lung?Cancer2022

    • Author(s)
      Sato Y, Sumikawa H, Shibaki R, Morimoto T, Sakata Y, Oya Y, Tamiya M, Suzuki H, Matsumoto H, Yokoi T, Hashimoto K, Kobe H, Hino A, Inaba M, Tsukita Y, Ikeda H, Arai D, Maruyama H, Hara S, Tsumura S, Sakata S, Fujimoto D
    • Journal Title

      CHEST

      Volume: 162 Pages: 1188~1198

    • DOI

      10.1016/j.chest.2022.05.035

    • Peer Reviewed / Open Access
  • [Journal Article] Epidemiology of adverse drug events and medication errors in four nursing homes in Japan: the Japan Adverse Drug Events (JADE) Study2022

    • Author(s)
      Ayani N, Oya N, Kitaoka R, Kuwahara A, Morimoto T, Sakuma M, Narumoto J
    • Journal Title

      BMJ Quality Safety

      Volume: 31 Pages: 878~887

    • DOI

      10.1136/bmjqs-2021-014280

    • Peer Reviewed / Open Access
  • [Journal Article] Over Half of Falls Were Associated with Psychotropic Medication Use in Four Nursing Homes in Japan: A Retrospective Cohort Study2022

    • Author(s)
      Oya N, Ayani N, Kuwahara A, Kitaoka R, Omichi C, Sakuma M, Morimoto T, Narumoto J
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 19 Pages: 3123~3123

    • DOI

      10.3390/ijerph19053123

    • Peer Reviewed / Open Access
  • [Presentation] Medical errors and error-related adverse events in pediatric inpatients in Japan: The JET Study2023

    • Author(s)
      Sakuma M, Takeuchi J, Ohta Y, Morimoto T
    • Organizer
      39th International Conference of the International Society for Quality in Health Care
    • Int'l Joint Research
  • [Presentation] Computerized clinical decision support system to adhere to pre-prescription examinations for high-risk drugs2023

    • Author(s)
      Nezu M, Nakamura T, Sakuma M, Morimoto T
    • Organizer
      39th International Conference of the International Society for Quality in Health Care
    • Int'l Joint Research
  • [Presentation] Incidence and clinical impact of delirium after transcatheter aortic valve implantation in Japan: An interim report2023

    • Author(s)
      Ayani N, Zen K, Morimoto T, Narumoto J
    • Organizer
      39th International Conference of the International Society for Quality in Health Care
    • Int'l Joint Research
  • [Presentation] Clinical decision support system to reduce inappropriate medication orders in outpatient service2022

    • Author(s)
      Nakamura T, Kosaka S, Sonoyama T, Morimoto T
    • Organizer
      38th International Conference of the International Society for Quality in Health Care
    • Int'l Joint Research
  • [Presentation] The Incidence and characteristics of adverse events in pediatric inpatients in Japan: The JET Study2022

    • Author(s)
      Sakuma M, Takeuchi J, Ohta Y, Morimoto T
    • Organizer
      38th International Conference of the International Society for Quality in Health Care
    • Int'l Joint Research
  • [Presentation] The Epidemiology of unidentified adverse events in Japan: The JET Study2022

    • Author(s)
      Ohta Y, Sakuma M, Nakamura T, Morimoto T
    • Organizer
      38th International Conference of the International Society for Quality in Health Care
    • Int'l Joint Research
  • [Presentation] Clinical epidemiology in violence and violation in psychiatric inpatients: The GUARD Study: An interim report2022

    • Author(s)
      Ayani N, Sakuma M, Narumoto J, Morimoto T
    • Organizer
      38th International Conference of the International Society for Quality in Health Care
    • Int'l Joint Research

URL: 

Published: 2024-12-25  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi