2023 Fiscal Year Final Research Report
A validation epidemiological study of a comprehensive risk algorithm for lifestyle-related diseases in a community-based population
| Project/Area Number |
21H03206
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
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| Research Institution | Kurume University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中杤 昌弘 名古屋大学, 医学系研究科(保健), 准教授 (10559983)
市原 佐保子 自治医科大学, 医学部, 教授 (20378326)
松原 達昭 愛知みずほ大学, 人間科学部, 教授 (30209598)
加藤 倫子 国際医療福祉大学, 国際医療福祉大学成田病院, 准教授 (30450886)
山本 健 久留米大学, 医学部, 教授 (60274528)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 生活習慣病 / GWAS / 心疾患 / miRNA / ゲノム疫学 / DNAメチル化 |
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| Outline of Final Research Achievements |
In today's aging society, the establishment of preventive methods against lifestyle-related diseases, including cardiovascular diseases, is an important issue in medicine and medical care in Japan. In this study, using the cross-sectional research platform we have accumulated in the past, we participated in domestic and international consortiums to conduct genome-wide association analysis and succeeded in further identification of risk markers for four major lifestyle-related diseases: type 2 diabetes, hypertension, dyslipidemia, and obesity. Furthermore, as an independent study, we focused on microRNAs in blood and succeeded in identifying microRNAs associated with coronary artery disease by using samples from our prospective cohort study.
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| Free Research Field |
循環器内科学
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| Academic Significance and Societal Importance of the Research Achievements |
高齢化社会を迎えた現在の我が国において、循環器疾患を含む生活習慣病に対する予防法の確立は、医学・医療における重要な課題である。本研究で同定されたリスクマーカーと従来の古典的リスクマーカーを統合したリスク診断アルゴリズムによって、従来よりも高精度なリスク予測が可能になる。最終的には、このアルゴリズムが生活習慣病の発症予防（個別化予防）に貢献し、健康寿命の延長に資することが期待される。
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