2023 Fiscal Year Final Research Report
Senorehabilitation: A novel approach to tissue regeneration based on cellular senescence
Project/Area Number |
21H03293
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 59010:Rehabilitation science-related
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Research Institution | Sapporo Medical University |
Principal Investigator |
Saito Yuki 札幌医科大学, 医学部, 講師 (40758702)
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Co-Investigator(Kenkyū-buntansha) |
齋藤 貴子 (千見寺貴子) 北海道大学, 保健科学研究院, 教授 (40452982)
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Project Period (FY) |
2021-04-01 – 2024-03-31
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Keywords | 細胞老化 / 再生 / リハビリテーション / エクササイズ / 糖尿病 |
Outline of Final Research Achievements |
Senescent cells secrete various bioactive factors, such as cytokines and growth factors, which influence surrounding cells to promote tissue regeneration. Our previous research has suggested that mechanical stimulation can modulate cellular senescence, leading to the concept of "Senorehabilitation." This approach aims to control cellular senescence through rehabilitation to enhance tissue regeneration, and its potential has been investigated.
In this study, we identified cell populations that are more prone to senescence induction through in vitro experiments and single-cell RNA-seq analysis of mouse skeletal muscle post-exercise. Additionally, we discovered that different cell populations are more susceptible to senescence induction in the skeletal muscle of obese mice following exercise.
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Free Research Field |
リハビリテーション
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Academic Significance and Societal Importance of the Research Achievements |
細胞老化はサイトカインや成長因子など様々な生理活性因子を分泌することで周囲の細胞に働きかけて組織を再生へ導く一方、長期的に組織に蓄積することで慢性炎症を引き起こす原因細胞となる。この老化細胞を標的とした治療法の開発が、慢性炎症疾患および健康長寿達成のために大きな注目を集めている。本研究成果では、運動刺激によって細胞老化が誘導されやすい細胞集団を同定に成功した。この成果は、メカニカルストレスおよびリハビリテーションによる細胞老化制御の達成に向けた基盤データとなり、将来的には健康長寿社会達成につながる可能性を有している。
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