2023 Fiscal Year Final Research Report
Elucidation of the mechanism by which myokines regulate aging progress
Project/Area Number |
21H03360
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 59040:Nutrition science and health science-related
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Research Institution | Kyushu University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
佐邊 壽孝 北海道大学, 遺伝子病制御研究所, 客員教授 (40187282)
高田 真吾 北翔大学, 生涯スポーツ学部, 准教授 (60722329)
松島 将士 九州大学, 医学研究院, 助教 (80552869)
横田 卓 北海道大学, 大学病院, 特任講師 (90374321)
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Project Period (FY) |
2021-04-01 – 2024-03-31
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Keywords | マイオカイン / 骨格筋 / 老化 / サルコペニア / プロテオーム解析 |
Outline of Final Research Achievements |
A myokine library was created by analyzing proteins secreted from skeletal muscle using mass spectrometry. In addition, by comparing the results of mass spectrometry analysis of blood from aging mice, we identified myokines that change with age (aging myokine profiling). We revealed that the secretion of brain-derived neurotrophic factor, a myokine, was decreased with age and was closely related to mitochondrial function and exercise capacity. We succeeded in observing the secretion dynamics of brain-derived neurotrophic factor in real time using a confocal microscope. As a result of comprehensive analysis of Rab proteins, it became clear that two types of Rab proteins may be involved in the secretion of myokines from C2C12 cells.
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Free Research Field |
栄養学および健康科学関連
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Academic Significance and Societal Importance of the Research Achievements |
加齢によるマイオカイン分泌の全体像を捉えることはこれまでになかった独自の研究であり、本研究の学術的意義は極めて高い。加齢によって特異的に変化するマイオカインおよびそれらの分泌機構を明らかにすることによって、マイオカインによる新規薬物治療法の開発研究へ発展する。このことは、老化の共通基盤である骨格筋の量的・質的変化を予防・治療することにつながり、今後の健康長寿社会の実現に大きく寄与すると考えられ、社会的意義は高い。
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