2023 Fiscal Year Final Research Report
Understanding and controlling small intestinal development based on local stiffening
| Project/Area Number |
21H03790
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 90110:Biomedical engineering-related
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| Research Institution | Osaka University (2022-2023)
Saitama University (2021) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
竹見 祥大 埼玉大学, 理工学研究科, 助教 (70871440)
吉川 洋史 大阪大学, 大学院工学研究科, 教授 (50551173)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | メカノバイオロジー / オルガノイド / 細胞 / 膜 / 流動性 / 幹細胞 / 分化 / 顕微鏡開発 |
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| Outline of Final Research Achievements |
In FY 2021, the project leader and his colleague 1 (Assistant Prof. Yoshihiro Takemi) optimized the method for creating small intestinal organoids. In FY2023, together with Participant 2 (Prof. Hiroshi Yoshikawa), we achieved the analysis of the spatiotemporal dynamics of organoid membrane fluidity, which changes with the morphogenesis of small intestinal organoids. Having obtained initial data on the physical fingerprint of cell membrane fluidity specific to stem cells in the small intestine, we are currently working on a paper on the role of cell mechanical properties in the morphogenetic process of the small intestine.
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| Free Research Field |
メカノバイオロジー
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| Academic Significance and Societal Importance of the Research Achievements |
本プラットホームの構築により，局所硬化を担う細胞の物理学的，生物学的な役割が明らかとなり，オルガノイドのメカノバ イオロジーの分野を切り拓く基礎的なデータが得られるものと期待できる．以上の成果は，論文として11報(例:iScience 2022, J. Phys Chem Letter 2022(Supplimentary Cover art), 2024など)，さらに国際シンポジウム発表2件，招待講演3 件，受賞1件(第65回日本平滑筋学会総会 )の成果創出を通して，代表者が専門とする学問業界だけでなく，多様な医学，生物学社会に対する成果還元につながったと考えられる．
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