Development of a handy system for rapid drug monitoring from tiny amounts of blood

2023 Fiscal Year Final Research Report

• Project/Area Number: 21H03805
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 90110:Biomedical engineering-related
• Research Institution: Keio University
• Principal Investigator: Ogata Genki 慶應義塾大学, 理工学部(矢上), 特任准教授 (80452829)
• Co-Investigator(Kenkyū-buntansha): 日比野 浩 大阪大学, 大学院医学系研究科, 教授 (70314317) ; 栄長 泰明 慶應義塾大学, 理工学部(矢上), 教授 (00322066) ; 楠原 洋之 東京大学, 大学院薬学系研究科(薬学部), 教授 (00302612) ; 椎木 弘 大阪公立大学, 大学院工学研究科, 教授 (70335769)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 導電性ダイヤモンド電極 / 薬物動態 / 分子インプリント / TDM

Outline of Final Research Achievements

Simple monitoring of drug concentrations in blood is required to improve the efficacy and safety of drug treatment. Electrochemical methods enable rapid measurement, but quantification has been problematic when substances react at the same potential. Therefore, we developed an MIP-BDD electrode with a molecularly implanted polymer (MIP) modified on boron-doped diamond (BDD) for selective drug detection: the MIP traps specific molecules and can selectively detect target molecules in a mixture. In this study, the anticancer drug doxorubicin (DOX) was used as a template molecule, and only DOX showed a reduction reaction at the MIP-BDD electrode. DOX can also be measured in plasma and is expected to be applied to drug blood concentration monitoring.

Free Research Field

生体医工学

Academic Significance and Societal Importance of the Research Achievements

本研究で開発した血漿中薬物測定システムは、ダイヤモンド電極にMIPを修飾したセンサーにより、従来の大型分析装置が不要で、迅速・簡便・安価に薬物を測定できる。この成果により、効果を最大化し副作用を最小限にする投薬方法の開発、過剰投与の抑制と医療費削減、臨床医学や薬物動態学の新たな分析ツールの提供が期待される。