2023 Fiscal Year Final Research Report
Development of ultrasound-responsive nanobubbles specialized on heart failure and construction of a disease treatment system
| Project/Area Number |
21H03843
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 90130:Medical systems-related
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
吉川 大和 東京薬科大学, 薬学部, 准教授 (20274227)
高橋 葉子 (遠藤葉子) 東京薬科大学, 薬学部, 講師 (30453806)
濱野 展人 東京薬科大学, 薬学部, 講師 (80708397)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | ナノバブル / 超音波 / 心不全 |
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| Outline of Final Research Achievements |
In recent years, analysis of heart failure pathology has clarified the targets for drug discovery, and nucleic acid drug therapy has been attracting attention. However, the useful DDS is an urgent issue. In this study, we developed ultrasound-responsive nanobubbles loaded with miRNAs that have the ability to inhibit fibrosis associated with heart failure, and successfully delivered therapeutic miRNAs into the hearts of mouse model of drug-induced chronic heart failure. In fact, the combination of nanobubbles and therapeutic ultrasound irradiation suppressed the expression of fibrosis- and inflammation-related factors in the miRNA-transfected hearts of heart failure models. Therefore, this nanobubble miRNA delivery system is expected to be a useful tool in the treatment of heart failure.
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| Free Research Field |
超音波DDS
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| Academic Significance and Societal Importance of the Research Achievements |
薬剤誘発性慢性心不全モデルマウスを利用した治療研究において、超音波応答性ナノバブルにより、線維化抑制能を有するmiRNAを心臓へと送達させ、実際に機能発現したという結果は、他の循環器疾患治療にも適用可能と考えられる。多様なmiRNAや再生関連因子などのmRNAを組合わせることで治療効率を向上でき、がん治療や再生医療分野における新たな治療システム開発に発展する可能性を秘めている。本研究成果は、超音波診断造影能を有するナノバブルを用いることで、疾患部位の診断と治療の一体化システム （セラノスティクス）の構築に繋がり、学術的及び社会的にも大きな意義があると考えられる
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