2023 Fiscal Year Final Research Report
Study on the optimal control of cardiomyocytes beating in chronic hemodialysis treatment
| Project/Area Number |
21H03848
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 90140:Medical technology assessment-related
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
崎山 亮一 大阪工業大学, 工学部, 准教授 (30408471)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 慢性血液透析療法 / 心筋細胞拍動能 / 電気生理学 / 計算機シミュレーション / 医療技術評価 / 拍動リズム / 収縮力 |
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| Outline of Final Research Achievements |
In this study, we were the first in the world to use a mathematical model based on electrophysiology to closely examine the relationship between fluctuations in plasma K+ concentration (KP) during hemodialysis treatment and cardiomyocyte contractility. First, we found that a decrease in KP led to an extension of the depolarization phase in ventricular myocytes due to the reduced rate of potassium efflux through the Kr channel, temporarily enhancing contractile force. Next, an excessive decrease in KP increased the transport of K+ and Na+ through the Funny channels in sinoatrial node cells, disrupting automaticity and causing a significant drop in the membrane potential of ventricular myocytes, leading to contractile failure. Avoiding excessive reductions in KP during treatment contributed to the maintenance of cardiomyocyte contractility. Our findings strongly suggest the need to optimize or finely control the K+ concentration in the dialysis solution based on pre-dialysis KP levels.
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| Free Research Field |
医用工学 電気生理学 システム生物学 計算機科学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果の「拍動能安定化を目的に治療中の透析液電解質濃度を動的制御する治療戦略」は前例のない独創的研究であり、また、我々が有する透析治療催不整脈等数理解析基盤は世界唯一の技術である。そして、本研究は細胞外液の時空間的電解質動態が生体機能の秩序形成に寄与することを明らかにし、細胞外液の電解質濃度の調節を通して生体機能を操作する研究分野を創造するものである。本研究課題の成果は急性血液浄化、長時間透析治療、肝不全療法など幅広い血液浄化療法に極めて高い波及効果を有する。本研究成果の一部は臨床応用され、患者の生命予後向上に貢献している。
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