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2023 Fiscal Year Final Research Report

Spatio-temporal regulation of skeletal development by the Zfhx family of transcription platform factors.

Research Project

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Project/Area Number 21H04841
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 57:Oral science and related fields
Research InstitutionOsaka University

Principal Investigator

Nishimura Riko  大阪大学, 大学院歯学研究科, 教授 (60294112)

Co-Investigator(Kenkyū-buntansha) 村上 智彦  大阪大学, 大学院歯学研究科, 講師 (50510723)
高畑 佳史  大阪大学, 大学院歯学研究科, 助教 (60635845)
波多 賢二  大阪大学, 大学院歯学研究科, 准教授 (80444496)
Project Period (FY) 2021-04-05 – 2024-03-31
Keywords骨格形成 / 軟骨代謝 / 骨代謝 / 転写因子
Outline of Final Research Achievements

The human and other vertebrate skeletons are formed from two distinct modes of osteogenesis, membranous and endochondral osteogenesis, which dynamically fluctuate gene expression required for skeletal development and the differentiation and maturation of undifferentiated mesenchymal stem cells into osteoblasts or chondrocytes. This study reveals a novel regulatory mechanism of vertebrate skeletogenesis by the Zfhx family of transcription factors, which, in conjunction with the transcription factors Runx2 and Osterix, which are essential for osteogenesis and cartilage formation, function as a platform for these transcription factors. The Zfhx family functions as a platform for these transcription factors in conjunction with Runx2 and Osterix, which are essential for bone and cartilage formation. Zfhx3 and Zfhx4 were also suggested to regulate osteogenesis and cartilage formation in a compensatory manner.

Free Research Field

分子生物学

Academic Significance and Societal Importance of the Research Achievements

膜性骨形成および内軟骨性骨形成過程がどのようなメカニズムで細胞あるいは遺伝子レベルで連続的かつダイナミックに制御されているかは不明であったが、本研究成果により、転写因子ZfhxファミリーがRunx2やOsterixと協調し、これら転写因子のプラットフォームとして機能することが示され、骨格制御過程における新規概念の創出に貢献した。この新規概念は、他の組織の臓器の発生あるいは再生過程の理解にも貢献できると期待される。また本研究成果は、ヒト骨格形成異常疾患の病因解明とその病態の理解にも寄与し、社会的意義にも寄与すると思われる。

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Published: 2025-01-30  

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