2023 Fiscal Year Final Research Report
Development of coherent Raman scattering microendoscope and application to unstained in-situ diagnosis
| Project/Area Number |
21H04950
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Medium-sized Section 90:Biomedical engineering and related fields
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
七戸 俊明 北海道大学, 医学研究院, 准教授 (70374353)
新岡 宏彦 大阪大学, データビリティフロンティア機構, 特任准教授(常勤) (70552074)
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| Project Period (FY) |
2021-04-05 – 2024-03-31
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| Keywords | ラマンイメージング / 内視鏡 / 非線形光学 |
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| Outline of Final Research Achievements |
An endoscopic optical system using coherent anti-Stokes Raman scattering (CARS) was investigated to realise an endoscope that enables in situ diagnosis without staining. We proposed a method to avoid light emission from the optical fiber itself, which is a problem when transmitting and imaging excitation light using an optical fiber bundle. We showed that CARS observation is possible by reducing the emission from the optical fiber to 1/3289. We also investigated methods for scanning and controlling the excitation beam's polarisation to improve CARS light emission efficiency. Furthermore, we have studied an image reconstruction method using deep learning to remove the structure of the optical fiber bundle to obtain higher-resolution images.
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| Free Research Field |
生体光計測
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| Academic Significance and Societal Importance of the Research Achievements |
消化管内視鏡での検査では，その場で確定診断することは難しく，生検により組織の一部を取り出して確定診断を行う．もし生検を行わずに，しかも安全のために無染色にその場で確定診断を行うことができれば，安全性の向上，患者の負担の軽減，医療コストの削減を達成することが可能となる．このような顕微内視鏡を実現するための光学系システムの検討を行い，イメージングが可能であることを示し，さらにより大きな信号を取得する手法，高精細な画像を取得する方法の開発を行なった．
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