2021 Fiscal Year Annual Research Report
Modulation of priming TBS with NMES on neuroplasticity and clinical rehabilitation effects on focal hand dystonia
| Project/Area Number |
21J10563
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| Research Institution | The University of Tokyo |
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Principal Investigator |
曹 娜 東京大学, 総合文化研究科, 特別研究員(DC2)
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| Project Period (FY) |
2021-04-28 – 2023-03-31
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| Keywords | Theta burst stimulation / Plasticity / Priming / NMES |
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| Outline of Annual Research Achievements |
Two studies have been completed. The first study, which combine cortical and peripheral stimulations sequentially, has been published in the journal Experimental Brain Research. The second study, which tested the dose effect of the concurrent and associative electrical stimulation, its preliminary results has been presented in the conference “International Functional Electrical Stimulation Society (IFESS) RehabWeek”.
The project will lead to the development of new neuromodulation method that uses non-invasive brain stimulation and afferent recruitment.
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| Current Status of Research Progress |
Current Status of Research Progress
3: Progress in research has been slightly delayed.
Reason
In the original schedule, the experimental plan consisted of two parts: Study 1: effects of combined TBS with NMES on excitability of corticospinal circuits in healthy subjects and study 2: effects of TBS and NMES associative stimulation for treatment of focal hand dystonia patients. However, due to covid-19 epidemic, it's hard to recruit the dystonia patients. Therefore, the study 2 for dystonia patients has been postoned.
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| Strategy for Future Research Activity |
In this year, since it's hard to recruit hand dystonia patients, the proposal will be focus on the further development on the new paradigm for neuroplasticity improvement with sychronized cortical intermittent theta brust stimulation (iTBS)and peripheral electrical stimulation using neuromuscular electrical stimulation (NMES). The objective of this study is to compare the corticospinal excitability induced by cortical iTBS and concurrent or delayed NMES, as well as cortical iTBS and synchronized or asynchronized NMES. If it works, a new and more more effective protocal to further increase the neuroplasticity would be benefit for future clinical implications.
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Research Products
(2 results)
