2023 Fiscal Year Final Research Report
Development of a novel oral cancer therapy utilizing the anti-tumor effect and immune activation by atmospheric pressure plasma.
| Project/Area Number |
21K03524
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 14030:Applied plasma science-related
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| Research Institution | Saga University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
合島 怜央奈 佐賀大学, 医学部, 講師 (30756143)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 大気圧プラズマ / 口腔がん / 免疫 |
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| Outline of Final Research Achievements |
Surgery, radiotherapy, and chemotherapy are the mainstays of oral cancer treatment, but they present various problems. Especially in today's hyper-aged society, many patients have various pre-existing conditions that make treatment difficult. The purpose of this study was to develop a new, safe and effective oral cancer treatment. By utilizing atmospheric pressure plasma, it was confirmed that an antitumor effect on oral cancer cell lines could be obtained. On the other hand, it was also confirmed that invasion of normal cells is minimized. It was also found that irradiation of immune system cells with atmospheric plasma under certain conditions can activate immune functions.
Translated with www.DeepL.com/Translator (free version)
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| Free Research Field |
顎顔面外科
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| Academic Significance and Societal Importance of the Research Achievements |
今回の研究成果から、大気圧プラズマが口腔癌治療として活用できることが示唆された。つまり、抗腫瘍効果を維持したまま、従来の治療法で問題となる皮膚炎や口内炎といった副作用の出現が少ない治療法となり得る。高齢者や様々な既往症をもった患者など幅広い適応を有する新規の治療法になると考える。
また一方で、大気圧プラズマによって免疫系細胞の賦活化も確認されたことから、照射によって周囲に浸潤している免疫系細胞にも影響を及ぼすことで、自己の抗癌作用の向上も期待できる。この治療法が確立されれば、口腔癌治療に大きく貢献できると確信する。
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