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2021 Fiscal Year Annual Research Report

Origin of Enzymes: Study of Hyperbranched Polymer Scaffolded Nanoparticles

Research Project

Project/Area Number 21K03735
Research InstitutionTokyo Institute of Technology

Principal Investigator

ママジャノフ イリーナ  東京工業大学, 地球生命研究所, 特任教授 (80776261)

Co-Investigator(Kenkyū-buntansha) ジャー トニーズィ  東京工業大学, 地球生命研究所, 特任助教 (10800328)
Project Period (FY) 2021-04-01 – 2022-03-31
Keywordshyperbranched polymer / polyester / wet-dry cycle / smart material / protoenzyme / biomimetic catalysis / chemical evolution / origin of life
Outline of Annual Research Achievements

We developed solid-state nuclear magnetic resonance (NMR) methods for detecting water bound and immobilized inside hyperbranched polymers. Based on the results we were able to classify the different polymers based on their water content. This property will become important at the later stages when designing catalysts for specific reactions. We optimized synthesize and analyze depsipeptide hyperbranched polymers. The polymers are synthesized by reacting a polyester matrix with amino acids. We have devised optimal amino acid mixes that allow for detectable selection without overwhelming the analysis.
We studied in more detail a lysine based hyperbranched polymer and it's catalytic ability. We found that polysine is capable of efficient catalysis of Kemp elimination.

  • Research Products

    (3 results)

All 2021

All Journal Article (3 results)

  • [Journal Article] Connecting primitive phase separation to biotechnology, synthetic biology, and engineering2021

    • Author(s)
      Jia Tony Z、Wang Po-Hsiang、Niwa Tatsuya、Mamajanov Irena
    • Journal Title

      Journal of Biosciences

      Volume: 46 Pages: 1~28

    • DOI

      10.1007/s12038-021-00204-z

  • [Journal Article] Incorporation of Basic α-Hydroxy Acid Residues into Primitive Polyester Microdroplets for RNA Segregation2021

    • Author(s)
      Jia Tony Z.、Bapat Niraja V.、Verma Ajay、Mamajanov Irena、Cleaves H. James、Chandru Kuhan
    • Journal Title

      Biomacromolecules

      Volume: 22 Pages: 1484~1493

    • DOI

      10.1021/acs.biomac.0c01697

  • [Journal Article] Single-molecule origin of life scenario: Necessity and feasibility2021

    • Author(s)
      Mamajanov Irena
    • Journal Title

      Physics of Life Reviews

      Volume: 38 Pages: 143~144

    • DOI

      10.1016/j.plrev.2021.04.007

URL: 

Published: 2023-12-25  

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