2021 Fiscal Year Annual Research Report
Origin of Enzymes: Study of Hyperbranched Polymer Scaffolded Nanoparticles
| Project/Area Number |
21K03735
|
|---|
| Research Institution | Tokyo Institute of Technology |
|---|
Principal Investigator |
ママジャノフ イリーナ 東京工業大学, 地球生命研究所, 特任教授 (80776261)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ジャー トニーズィ 東京工業大学, 地球生命研究所, 特任助教 (10800328)
|
|---|
| Project Period (FY) |
2021-04-01 – 2022-03-31
|
| Keywords | hyperbranched polymer / polyester / wet-dry cycle / smart material / protoenzyme / biomimetic catalysis / chemical evolution / origin of life |
|---|
| Outline of Annual Research Achievements |
We developed solid-state nuclear magnetic resonance (NMR) methods for detecting water bound and immobilized inside hyperbranched polymers. Based on the results we were able to classify the different polymers based on their water content. This property will become important at the later stages when designing catalysts for specific reactions. We optimized synthesize and analyze depsipeptide hyperbranched polymers. The polymers are synthesized by reacting a polyester matrix with amino acids. We have devised optimal amino acid mixes that allow for detectable selection without overwhelming the analysis.
We studied in more detail a lysine based hyperbranched polymer and it's catalytic ability. We found that polysine is capable of efficient catalysis of Kemp elimination.
|
