Generation of laser-induced strong surface acoustic wave by piezoelectric-loaded device with a confined structure in challenges for transdermal administration

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K04202
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 21060:Electron device and electronic equipment-related
• Research Institution: Kanazawa Institute of Technology
• Principal Investigator: Aizawa Koji 金沢工業大学, 工学部, 教授 (40222450)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: パルスレーザ / 弾性表面波 / Lamb波 / 圧電体 / 人工皮膚

Outline of Final Research Achievements

The purpose of this study was to develop a device that can generate strong surface acoustic waves that promote permeation of transdermal drugs and highly efficient introduction of substances to the artificial skin surface. Specifically, we proposed the coupling of pulsed laser-induced Lamb waves on a spherical shell to the artificial skin surface while investigating methods of generating strong surface acoustic waves using a pulsed laser. In particular, we experimentally demonstrated that the use of a spherical shell with a black rubber attached to the laser irradiation area is effective in increasing the intensity of the Lamb waves generated on the spherical shell. The Lamb wave intensity measured using a biological phantom with a piezoelectric membrane loaded through an artificial skin was found to be strong enough for transdermal drug delivery.

Free Research Field

電子デバイス、波動応用デバイス、電気電子材料工学

Academic Significance and Societal Importance of the Research Achievements

経皮薬剤導入でこれまで検討された手法のほとんどが皮膚の穿孔を伴う侵襲的な皮下投与であった。本研究では皮膚に瞬間圧力を加えるとその物質透過性が一時的に促進することに注目し、皮膚表面に音響エネルギーを集中させることを考えた。本研究は皮膚の穿孔なしに低侵襲で薬剤を皮内に導入・留める新たな皮内投与法の開発につながる点で社会的な意義がある。本研究では皮膚表面に音響エネルギーを集中させる方法としてレーザ誘起Lamb波の利用を提案し、その発生と人工皮膚への音響結合を実験的に評価した成果は新たな知見を与えており学術的意義があると考える。