High throughput capsulation of pseudo blood cells and analysis of mechanical properties for them by highly accurate rheological measurement.

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K04863
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 29010:Applied physical properties-related
• Research Institution: Meiji University
• Principal Investigator: Hirano Taichi 明治大学, 理工学部, 専任准教授 (00401282)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 粘度計測 / 流動特性

Outline of Final Research Achievements

As a foothold for analyzing flow characteristics of human blood, we achieved a high throughput capsulation of pseudo blood cells whose size and mechanical properties are arbitrarily adjustable, and measured the degree of change in viscosity curve for dispersion system of the originally made microparticles by the electromagnetically spinning method. Although an optimal function for quantitative evaluation of mechanical properties of microparticles, it was confirmed that viscosity of their dispersion system follows a power law for the shear rate, especially in the shear rate corresponding to bloodstream in a human body. In addition, there is difference in graph trajectory for rheological data when decelerating or accelerating the shear rate. Then, an appropriate way to interpret this behavior as well as a unique measurement protocol for avoiding sedimentation of micro particles and/or adsorption onto the liquid surface.

Free Research Field

複雑流体のレオロジー

Academic Significance and Societal Importance of the Research Achievements

インクジェット技術を応用した空中マイクロカプセル生成では，射出前の試料液体同士の表面張力のバランスを制御するだけで最終的な生成構造を調整できる。また，空中を反応場にしていることで，MEMSやNEMSなどの液中での生成に比べて，１００倍程度スループットを向上させることができるという特長がある。本研究の測定結果により，分散粒子が柔らかさを持っているだけで，非ニュートン挙動が大きく表れること，この現象がどのくらいの濃度域から顕著になるかを明らかにした点は，重要である。また，沈殿の影響が測定に与える影響の評価と，この影響を避けるような測定スキームの発見は，今後の分散系レオロジー計測の可能性を広げた。