Development of a novel modification method for the furoxan ring to enable diverse transformations of universal functional groups

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K05054
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 33020:Synthetic organic chemistry-related
• Research Institution: Kobe University
• Principal Investigator: Matsubara Ryosuke 神戸大学, 理学研究科, 教授 (90401223)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: フロキサン / 官能基修飾 / ラジカル

Outline of Final Research Achievements

In organic synthesis, a method to convert readily available functional groups into other functional groups under mild conditions is an important technique for molecular modification in fields such as pharmaceuticals. This time, by utilizing the furoxan skeleton, we were able to develop a short-step transformation method for universal functional groups. Furoxans are typically considered minor molecules, rarely seen in fields such as pharmaceuticals, agrochemicals, and materials. This achievement brings out the potential usefulness of these molecules, and it is expected that furoxans will receive more attention from researchers in the future, accelerating research and development.

Free Research Field

有機合成

Academic Significance and Societal Importance of the Research Achievements

創薬においては、多くの類縁体分子を合成しその薬理活性を調べ、最も薬効が高く最も毒性が低い分子の探索を行う。類縁体分子の合成には有機合成が用いられ、迅速な合成が求められる。多くの類縁体を合成するには、共通の中間体を準備し、その中間体を多様に分子修飾する方法が高効率となる。そのためには、一つの部分構造から多様な部分構造へと変換できる手法が必要である。本研究では、フロキサン分子を利用することでそれを実現した。