Development of surface-enhanced rotational spectroscopy method and its application to in situ visualisation of molecular isomerisation

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K05106
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 34020:Analytical chemistry-related
• Research Institution: Muroran Institute of Technology
• Principal Investigator: Takase Mai 室蘭工業大学, 大学院工学研究科, 准教授 (20631972)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 表面プラズモン / 表面増強分光 / 比旋光度 / エナンチオマー / 微量分析 / キラル分子検出 / 分子分別

Outline of Final Research Achievements

In this study, we developed a method to detect the optical rotation of molecules that are usually undetectable at the single-molecule level by placing chiral molecules in a strong electromagnetic field in which surface plasmon resonance is generated. As a result, it was found that by adsorbing molecules with optical rotation on the surface of noble metal particles, the absorption due to SPR has optical rotation and the optical rotation of the adsorbed molecules is significantly increased. This phenomenon responded nonlinearly to the amount of noble metal nanoparticles, suggesting that the enhancement due to coupling of SPRs when the metal particles are complexable rather than monoparticles also affects the increase in the degree of optical rotation. Thus, highly sensitive measurements were possible, indicating the possibility of in-situ dynamic observation.

Free Research Field

光無機材料化学

Academic Significance and Societal Importance of the Research Achievements

これまで物質固有の比旋光度を有するため，測定が難しいとされてきた微小な旋光度の変化について，その旋光度を増強することにより，通常の旋光度計をもちいて計測することが可能となった．これにより，非常に低い濃度で含まれる，毒性の強い分子を，in situの旋光度計測により見つけることが可能となる．このような理工学分野の基礎的な知見によって，医療をはじめとする人の生活に直結する化学技術となると考えていいる．