2023 Fiscal Year Final Research Report
Development of light-dependent apoptosis induction by lactosome-loaded pre-miR-664a
Project/Area Number |
21K05277
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 37010:Bio-related chemistry
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Research Institution | Okayama University |
Principal Investigator |
Watanabe Kazunori 岡山大学, ヘルスシステム統合科学学域, 准教授 (70602027)
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Project Period (FY) |
2021-04-01 – 2024-03-31
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Keywords | pre-miR-664a / 光制御 / アポトーシス誘導 |
Outline of Final Research Achievements |
Apoptosis induction methods are important in cancer therapy. We have reported that the combination of light-induced RNA delivery and pre-miR-664a, which induces apoptosis, can induce apoptosis in a light-dependent manner. However, the light-induced RNA delivery is difficult to use in vivo. Therefore, we attempted to develop a light-dependent apoptosis induction by loading pre-miR-664a and a photosensitizer onto lactosome that maintain high stability in vivo. As a result, apoptosis was induced in a light-dependent manner by lactosome loaded with pre-miR-664a and a photosensitizer, and lactosome loaded with pre-miR-664a and photosensitizer showed higher apoptosis induction efficiency than those loaded with a photosensitizer alone.
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Free Research Field |
生体分子工学
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Academic Significance and Societal Importance of the Research Achievements |
高効率なアポトーシス誘導が可能なpre-miR-664aと光増感剤を担持したラクトソームの開発に成功した。今後、in vivo研究へと発展させていくことで、pre-miR-664aと光増感剤を担持したラクトソームを用いた抗がん剤へと開発していくと考えている。
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