Isolation, structure elucidation and biological activity of compounds from marine cyanobacteria for lifestyle-related diseases

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K05291
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
• Research Institution: University of the Ryukyus
• Principal Investigator: Toshiaki Teruya 琉球大学, 教育学部, 教授 (90375428)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: Odookeanyne / Okeaniamide / デブロモアプリシアトキシン / 3T3-L1前駆脂肪細胞

Outline of Final Research Achievements

Odookeanyne A, B and okeaniamide A, B were isolated from the marine cyanobacterium Okeania sp. collected from the coast of Itoman City and their structures were elucidated by spectroscopic techniques. These compounds dose-dependently promoted the differentiation of mouse 3T3-L1 preadipocytes in the presence of insulin. In addition, a search for compounds that promote lipolytic activity yielded debromoaplysiatoxin. It was suggested that debromoaplysiatoxin promotes lipolysis in hypertrophic adipocytes and inhibits differentiation of mouse 3T3-L1 preadipocytes.

Free Research Field

天然物有機化学

Academic Significance and Societal Importance of the Research Achievements

沖縄産海洋シアノバクテリアから3T3-L1前駆脂肪細胞の分化促進作用を有する化合物を探索した例や、成熟脂肪細胞に蓄積したトリグリセリドの分解を促進する化合物を探索した例はほとんどない。3T3-L1前駆脂肪細胞から脂肪細胞への分化を促進する化合物、成熟脂肪細胞に蓄積したトリグリセリドの分解を促進する化合物を沖縄産海洋シアノバクテリアから発見する事は、新たな生活習慣病予防、治療薬のリード化合物の発見につながる可能性があると考えられる。