2023 Fiscal Year Final Research Report
Effect of acetic acid on the activation of GPR43 in skeletal muscle and skeletal muscle function
| Project/Area Number |
21K05456
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 38050:Food sciences-related
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| Research Institution | Okayama Prefectural University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 骨格筋 / 呼吸代謝 / ミトコンドリア / 酢酸 / AMPK / GPR43 |
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| Outline of Final Research Achievements |
Aging is accompanied by the loss of skeletal muscle mass and function, with severe consequences on quality of life. Aged muscle contributes to a decline in metabolic, respiratory, and exercise functions. Mitochondrial function in skeletal muscles, which plays an essential role in maintaining health throughout life, declines during aging. In this study, the physiological funcition of acetic acid on the human skeletal muscle cells. Treatment of acetic acid stimulated the gene expression related to respirator metabolism and mitochondrial function. These results suggest that acetic acid supplementation may contribute to the improvement of skeletal muscle function.
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| Free Research Field |
食品機能学
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| Academic Significance and Societal Importance of the Research Achievements |
加齢に伴う生活機能低下の要因の一つとして、骨格筋系の老化や肥満が挙げられ、その成因として、ミトコンドリアの機能障害が関与することが知られている。本研究により、酢酸はヒト骨格筋におけるミトコンドリアの増幅機能、また骨格筋の呼吸代謝改善の機能を有することが示唆された。これより、食品から酢酸を摂取することにより、ヒトの加齢による骨格筋機能の低下やエネルギー代謝異常の改善に寄与できると考える
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