2023 Fiscal Year Final Research Report

A study on fruits allergy due to Gibberellin-Regulated Protein (GRP)

Research Project

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Project/Area Number	21K05463
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 38050:Food sciences-related
Research Institution	Fujita Health University
Principal Investigator	Futamura Kyoko 藤田医科大学, 医学部, 講師 (60596956)
Co-Investigator(Kenkyū-buntansha)	中村政志藤田医科大学, 医学部, 客員准教授 (30449467) 下條尚志藤田医科大学, 医学部, 客員准教授 (70410751) 松永佳世子藤田医科大学, 医学部, 教授 (80131192) 矢上晶子藤田医科大学, 医学部, 教授 (90367699) 鈴木加余子藤田医科大学, 医学部, 准教授 (90814369)
Project Period (FY)	2021-04-01 – 2024-03-31
Keywords	GRP / PFAS（花粉-食物アレルギー症候群） / 重症果物アレルギー / スギ・ヒノキ花粉症
Outline of Final Research Achievements	By the final year of the study, it was possible to analyze up to 36 fruits allergy cases that tested positive for the causative fruit and peach-extracted GRP, confirming that these cases were more severe and often required exercise or other co-factors at onset. Peaches were the most common cause of allergy, followed by oranges, and a total of 15 different fruits and vegetables. Cross-reactivity of GRP among various fruits was suggested. All cases showed sensitization to cedar and cypress pollen, while sensitization to other pollens was less common. Reactivity of IgE antibodies to cedar pollen GRP was higher in cases of peach extract GRP sensitization. Our results further support the hypothesis that cedar pollen GRPs cross-react with fruit-derived GRPs to induce this fruits allergy.
Free Research Field	アレルギー
Academic Significance and Societal Importance of the Research Achievements	これまでに果物アレルギーは口腔アレルギー症状が主体であり、症状は軽微なものと考えられていたが、重症な果物アレルギーの症例を集積することで世間一般に広く啓発活動を実施できるようになった。重症果物アレルギーの起こりやすい果物などを提示、注意喚起を行うことが可能になった。スギ花粉感作と重症果物アレルギーとの関係性をより明らかにしたころから、これらのアレルギーがスギ花粉症に対する免疫療法で改善する可能性を示すことができたが、これについては今後更なる解析が必要と考えている。