2023 Fiscal Year Final Research Report
Involvement of the transcriptional repressor Bach1 in the maintenance of colonic mucus
| Project/Area Number |
21K05471
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 38050:Food sciences-related
|
|---|
| Research Institution | Ishikawa Prefectural University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2021-04-01 – 2024-03-31
|
| Keywords | ゴブレット細胞 / ムチン / 大腸がん / 炎症性腸疾患 / 糖鎖 / Bach1 / レクチン |
|---|
| Outline of Final Research Achievements |
The maintenance of the colonic mucus layer is involved in the development of colorectal cancer. Thus, maintaining a strong mucus layer is essential for the prevention of colorectal cancer. However, the mechanism of mucus secretion in the large intestine is still unclear. In this study, we reveal that BTB domain and CNC homolog 1 (Bach1), a transcriptional repressor, is involved in the qualitative regulation of colonic mucus. The results using Bach1-deficient mice showed that sialic acid and N-acetylgalactosamine in the colonic mucus glycan increased in Bach1-deficient mice, compared with that of wild type mice. In addition, regulation of the expression of glycosyltransferases may be partially involved in the Bach1-mediated qualitative regulation of colonic mucus.
|
| Free Research Field |
食品生化学
|
| Academic Significance and Societal Importance of the Research Achievements |
本邦における大腸がん罹患者は増加の一途を辿っている．また，大腸がんの発症には，大腸粘液層の脆弱化が深く関与する．本研究では，転写抑制因子であるBach1が大腸粘液の質的制御に関わることが新たに判明した．従って，Bach1は大腸がん予防における新たな分子標的となる可能性が示唆された．また，大腸粘液層の脆弱化に伴う腸管炎症は，大腸がん以外にも，糖尿病など多くの疾患発症と密接に関与している．そのため，上述の研究成果は多くの疾病の予防や進行抑制に対して大きな波及効果をもたらすことが期待できる．
|
