2023 Fiscal Year Final Research Report
Precise analysis of deamidated vitamin B12 compounds in foods and their physiological effects on mammalian cells
| Project/Area Number |
21K05488
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 38050:Food sciences-related
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | ビタミンB12 / 脱アミド化ビタミンB12 / 牛レバー / 魚卵製品 / 魚醤油 / 魚発酵食品 / シュードビタミンB12 / ビタミンB12カルボン酸 |
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| Outline of Final Research Achievements |
Crustaceans such as shrimp, which we commonly consume, and their processed food products were found to contain high levels of various types of deamidated vitamin B12. However, other seafood products and animal foods, such as beef liver, which are sources of vitamin B12 in Japan, contained only trace amounts. It has been suggested that deamidated vitamin B12 is less likely to inhibit the vitamin B12 metabolic system in human cells due to its poor intestinal absorption.
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| Free Research Field |
食品科学
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| Academic Significance and Societal Importance of the Research Achievements |
我々が日常的に摂取しているエビや他の甲殻類及びその加工品に含まれるビタミンB12とは構造が異なる脱アミド型ビタミンB12の存在を世界で初めて明らかにした．この発見は学術的に非常に意義深い．また，本研究により脱アミド型ビタミンB12は甲殻類とその加工品以外の動物性食品にはほんの微量しか存在しないことが判明した．この研究結果から，バランスの取れた食生活を送っていれば，ビタミンB12欠乏による神経障害の発症リスクは低いことが示唆された．
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