Prevention of brain tissue regeneration by T cells

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K05937
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 42020:Veterinary medical science-related
• Research Institution: Yamaguchi University
• Principal Investigator: Sakurai Masashi 山口大学, 共同獣医学部, 准教授 (00747967)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 脳 / マウス / Trimethyltin / 再生 / 免疫 / リンパ球

Outline of Final Research Achievements

In this study, the influence of T cell repopulation on brain tissue regeneration was investigated. CD4+ helper or CD8+ cytotoxic T lymphocytes were repopulated in nude mice and used as a mouse model for brain tissue regeneration by trimethyltin (TMT) injection. Brain tissue regeneration and associated changes were examined immunohistochemically. In both CD4+ and CD8+ repopulated groups, neuronal regeneration was inhibited. In addition, neurogenesis was declined and glial activations were altered. Thus, in TMT-injected mouse model, both helper and cytotoxic T cells are thought to prevent brain tissue regeneration through affecting neurogenesis and glial activations.

Free Research Field

神経病理

Academic Significance and Societal Importance of the Research Achievements

脳および脊髄から構成される中枢神経系は、一度損傷すると再生することは無いと考えられてきた。しかし、近年の研究により脳にも微弱な再生力が存在する可能性が示唆されており、また、多能性幹細胞等を用いた再生医療研究が中枢神経系においても精力的に行われている。本研究は、哺乳類の脳に再生が生じるTMT投与マウスモデルを解析し、その脳組織再生機序の一端を解き明かすことで、これら中枢神経系の再生医療分野の発展に貢献するものである。