2023 Fiscal Year Final Research Report
Epidemiological clarifications and evaluation of the pathogenesis about novel zoonotic Campylobacter distributed among wild lives
Project/Area Number |
21K05962
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 42020:Veterinary medical science-related
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Research Institution | Nihon University |
Principal Investigator |
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Project Period (FY) |
2021-04-01 – 2024-03-31
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Keywords | Campylobacter / 野生動物 / 鹿 / 猪 / 病原性 |
Outline of Final Research Achievements |
In this study, we investigated (1) the prevalence of Campylobacter species among wild deer and wild boars, and found that that in wild deer (39.5%) was higher than in deer (5.5%); (2) For the future development of cgMLST, which could be applied for the establishment of a phylogenetic analysis method using the isolates from livestocks and environment, we developed a data base of WGS data on Campylobacter isolates from wild deer and wild boars. ③ Comprehensive analysis of pathogen-related candidate genes by WGS of Campylobacter isolates derived from wild deer and wild boars, and ④We investigated the ability of the strains for the attachment and following invasion test for a human intestinal epithelial cell line and showed that the strain may be pathogenic to humans.
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Free Research Field |
獣医公衆衛生学
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Academic Significance and Societal Importance of the Research Achievements |
近年、全国的に増加しすぎた野生鹿や猪の個体数調整のために捕獲した鹿や猪を食用利用する試みが各地で行われている。その一方で各種食中毒事例も報告されているが、野生鳥獣肉のリスク評価は、必ずしも十分行われていなかった。本研究では、ジビエのリスク評価の一環として、Campylobacterに着目して検討したところ、従来注目されていなかったC. hyointestinalisが高率に分布し、人へのリスクとなりうることを明らかにした。本成績は今後のリスク管理を行う上で基礎的なデータとして活用できる。
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