Studies on differentiation and immunosuppressive function of innate-type regulatory B cells

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K05970
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 42030:Animal life science-related
• Research Institution: Niigata University
• Principal Investigator: Touma Maki 新潟大学, 自然科学系, 准教授 (40542246)
• Co-Investigator(Kenkyū-buntansha): 片貝 智哉 新潟大学, 医歯学系, 教授 (00324682)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: B細胞 / 制御性B細胞 / 炎症制御 / Toll様受容体（TLR） / IL-10

Outline of Final Research Achievements

In this study, we attempted to elucidate the regulatory function and the mechanisms of innate-type regulatory B cells (Breg) that are activated and induced via innate immune receptors. As the results, we confirmed that a transcriptional regulator IκBNS positively regulates the differentiation and IL-10 production of innate-type Bregs via TLR stimulation, and that the suppressive function of B cells was observed in an IκBNS-dependent manner. In addition, the undefined factors other than IL-10 production was suggested as a immunosuppressive mechanism by innate-type Bregs. Although the details remain to be elucidated, the present study partially elucidated the immunoregulaory mechanisms by IκBNS-dependent innate-type Bregs.

Free Research Field

免疫学、動物生理学

Academic Significance and Societal Importance of the Research Achievements

本研究によって、これまでに情報の少なかった自然免疫型の制御性B細胞（Breg）の機能と炎症抑制機序の一端を明らかにすることができ、B細胞による免疫制御機構の包括的理解に重要な情報が得られた。自然免疫型Bregは、素早く容易に、しかも大量に誘導できることから、免疫系の第一次抑制機構として重要であると推察される。本研究の発展として、B細胞の抗炎症機能を利用した新しい免疫制御法の確立といった展開が期待される。