2023 Fiscal Year Final Research Report
Revealing the Role of Postnatal Theta Rhythm in Establishing Memory Consolidation Mechanism during REM Sleep
Project/Area Number |
21K06419
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 46030:Function of nervous system-related
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Research Institution | University of Tsukuba |
Principal Investigator |
Kumar Deependra 筑波大学, 国際統合睡眠医科学研究機構, 助教 (20747696)
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Co-Investigator(Kenkyū-buntansha) |
船戸 弘正 筑波大学, 国際統合睡眠医科学研究機構, 客員教授 (90363118)
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Project Period (FY) |
2021-04-01 – 2024-03-31
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Keywords | Sleep / Memory / Theta rhythm / Dreamless |
Outline of Final Research Achievements |
We found that learning and memory are sensitive to age in developing mice. Mice pups at the age of postnatal day 26 (P26) showed a significant increase in freezing behavior during fear conditioning and recall (24 h delay) compared to P17. Dreamless mice that exhibit low strength theta rhythm and less time in REM sleep did not display such age-dependent enhancement of learning and memory (unpublished results). We developed techniques to measure sleep parameters (EEG/EMG) and deep brain local field potentials (LFP) in neonatal mouse pups aged starting P17. We confirmed no effect of surgery on the growth and development of pups.
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Free Research Field |
sleep memory
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Academic Significance and Societal Importance of the Research Achievements |
Our results suggest that in neonatal mice, theta oscillations integrate various brain regions for fear learning and memory. Our established EEG/EMG/LFP recording method can be used to study mice models for developmental disorders in children.
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